Surfaces, Interfaces, and Applications
- Meron Debas
Meron Debas
Department of Chemistry, and National Center of Competence in Research Bio-inspired Materials, University of Fribourg, Chemin Du Musée 9, Fribourg 1700, Switzerland
Food Research and Innovation Center, University of Fribourg, Chemin Du Musée 9, Fribourg 1700, Switzerland
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- Dinh Phuong Trinh Nguyen
Dinh Phuong Trinh Nguyen
Department of Chemistry, and National Center of Competence in Research Bio-inspired Materials, University of Fribourg, Chemin Du Musée 9, Fribourg 1700, Switzerland
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- Andreas F. M. Kilbinger
Andreas F. M. Kilbinger
Department of Chemistry, and National Center of Competence in Research Bio-inspired Materials, University of Fribourg, Chemin Du Musée 9, Fribourg 1700, Switzerland
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- Artur Glavic
Artur Glavic
Paul Scherrer Institute, Center for Neutron and Muon Sciences, Forschungsstrasse 111, Villigen PSI 5232, Switzerland
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- Heinz Amenitsch
Heinz Amenitsch
Institute for Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz 8010, Austria
Elettra Sincrotrone Trieste, Area Science Park, Trieste 34149, Italy
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- Stefan Salentinig*
Stefan Salentinig
Department of Chemistry, and National Center of Competence in Research Bio-inspired Materials, University of Fribourg, Chemin Du Musée 9, Fribourg 1700, Switzerland
Food Research and Innovation Center, University of Fribourg, Chemin Du Musée 9, Fribourg 1700, Switzerland
*Email: [emailprotected]
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
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https://pubs.acs.org/doi/10.1021/acsami.5c02607
Published April 16, 2025
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The nanoconfinement of lipid self-assembled structures offers a dynamic environment for chemical reactions. It enables the integration of regents of various polarities, their alignment at the lipid/water interface for regiospecific reactions, and tailored reaction dimensions from restricted diffusion in the nanoconfinement. However, the effects of monomer integration and polymerization on the self-assembly structure and reaction products remain to be fully understood. Here, we report the photoinitiated polymerization of hydroxyethyl acrylate (HEA) within the inverse bicontinuous cubic structure of glycerol monooleate (GMO), yielding biocompatible hybrid materials. The initial structures are formed in bulk and as thin films on silicon wafers through the self-assembly of GMO molecules with water. Using small-angle X-ray scattering (SAXS) and grazing incidence (GI)SAXS, we find that HEA actively integrates into the lipid–water interface, modifying the self-assembled packing geometries. Photopolymerization triggered structural transformations and changes in orientation relative to the substrate surface. Nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography reveal larger polymer sizes and smaller polydispersity under nanoconfined conditions compared to polymerization in water. These findings enhance the understanding of self-assembled structures as reaction nanoconfinements and establish a foundation for advanced material design.
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© 2025 American Chemical Society
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- Chemical structure
- Phase transitions
- Polymerization
- Thin films
- Water
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 16, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
Request reuse permissions
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